Technical Challenges and Analysis of the Results in Kinship Cases that Appear to Comply with Murphy’s Law Workshop

Description:

Murphy’s Law says: “Everything that can go wrong will go wrong.” Using standard STR markers sets to establish biological relationships analysis complex can generate ambiguous data. Several drawbacks appear when a high enough likelihood ratio is not obtained, or not excluded with totally inconsistent genotypes. We could add other challenges such as no availability of close relatives, insufficient concentration or poor DNA quality, allelic discrepancies, mutation rate, triallelic patterns, etc. And further to that, the legal pressure behind the case. We will try to reverse the “bad luck” with different technical strategies and statistical analysis. This workshop will be presented in Spanish.

Learning Outcomes:

• Standard battery sets of STR markers not always can establish biological relationships.
• Relationship parentage complex test can generate ambiguous data and several drawbacks appear when a high enough likelihood ratio is not obtained, or not excluded with totally inconsistent genotypes.
• Different expert solutions to solve complex cases with more than one technical and/or statistical analysis challenge.

Intended Audience:

• Forensic geneticist investigator