Carol Schweitzer and Colin McNally of the National Center for Missing and Exploited Children (NCMEC) shed light on the transformative role of forensic DNA technology in aiding the identification of missing and exploited children. They delve into their collaborative efforts with various entities, including private labs and the US Secret Service’s Forensic Sciences Division, to harness a broad spectrum of DNA technologies. The conversation also covers the significant work of forensic artists and anthropologists at NCMEC in creating accurate age progressions and facial approximations, which are crucial in law enforcement’s pursuit of unresolved cases. Furthermore, they emphasize the importance of offering these resources free of charge to ensure every case receives the attention and resources it merits. Join us in exploring how the blend of art, science, and collaboration is paving the way towards a safer future for children across the nation.